Carcinogenic and Mutagenic Metal Compounds

Environmental and Analytical Chemistry and Biological Effects (Current Topics in Environmental and Toxicological Chemistry) by E. Merian

Publisher: Routledge

Written in English
Cover of: Carcinogenic and Mutagenic Metal Compounds | E. Merian
Published: Pages: 550 Downloads: 718
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  • Environmental science,
  • Toxicology (non-medical),
  • Oncology,
  • Cancer,
  • Environmental Toxicology,
  • Medical / Nursing,
  • Science/Mathematics,
  • Wood products,
  • Chemistry - General,
  • Science / Chemistry / General,
  • Chemical mutagenesis,
  • Carcinogenesis,
  • Metals,
  • Toxicology
The Physical Object
Number of Pages550
ID Numbers
Open LibraryOL9005687M
ISBN 102881240224
ISBN 109782881240225

- Consider biocompatibility and potential harm – irritant, toxic, allergenic, teratogenic, mutagenic, carcinogenic. - Any numerous natural or synthetic compounds of usually high molecular weight consisting of up to millions of repeated linked units, each a relatively light and simple molecule. 4. Alkyl-phenol-ethoxylades: mimics estrogen, used in shampoo, carcinogenic, mutagenic, toxic. Causes adverse reactions. Reduces sperm count. 5. Ammonium laureth sulphate: found in hair and bubble bath products. Laureth contains ether that is listed as carcinogenic, mutagenic, toxic and causes adverse reactions. 6. Luteolin is a flavonoid which is part of our daily nutrition in relatively low amounts (less than 1 mg/day). Nevertheless, some epidemiological studies suggest an inverse correlation between luteolin intake and the risk of some cancer types. Luteolin displays specific anti-inflammatory and anti-carcinogenic effects, which can only partly be explained by its anti-oxidant and free radical Cited by: Some heavy metals like copper, selenium, or zinc are essential trace elements, with functions indispensible for various biological processes also driving the entire human metabolism [ 2 ]. The heavy metal cobalt, acting as the central atom in the vitamin B12 complex, is a key player in the reductive branch of the propionic acid fermentation Cited by: 2.

Abstract: Metal-induced toxicity and carcinogenicity, with an emphasis on the generation and role of reactive oxygen and nitrogen species, is reviewed. Metal-mediated formation of free radicals causes various modifications to DNA bases, enhanced lipid peroxidation, and altered calcium and sulfhydryl homeostasis. The main objective of our work was to examine the feasibility of using the in vitro stimulation of biphenyl 2-hydroxylase by chemical carcinogens as a rapid prescreen for mutagenic and carcinogenic compounds to complement the presently available biological testing methods. Initial experiments were designed to duplicate exactly the work of others. Methods of acceptable risk levels are discussed in ICH Q3C(R3), Appendix 3, in reference to class 1 carcinogenic solvents. The EMEA guideline recognises these limitations and, therefore, proposes ‘TTC’ for GIs. The EMEA guideline recommends a TTC of . In this chapter, we discuss the influence of the processing methods on the content of phenolic compounds in fruits and vegetables. The intake of fruits and vegetables based‐foods are associated with delayed aging and a decreased risk of chronic disease development. Fruits and vegetables can be consumed in natura, but the highest amounts are ingested after some Cited by:

The preceding paper described our numerical index of carcinogenic potency, the TD 50 and the statistical procedures adopted for estimating it from experimental data. This paper presents the Carcinogenic Potency Database, which includes results of about long-term, chronic experiments of test by: carcinogenic or mutagenic potential of inorganic metal salts. Cancer Res *Cavallo D, Iavicoli I, Setini A, et al. Genotoxic risk and oxidative DNA damage in workers exposed to antimony trioxide. Environ Mol Mutagen 40(3) /em *CDC. Fourth national report on human exposure to environmental chemicals. present, or may present, through inhalation or other routes of exposure, a threat of adverse human health effects (including, but not limited to, substances which are known to be, or may reasonably be anticipated to be, carcinogenic, mutagenic, teratogenic, neurotoxic, which cause reproductive dysfunction, or which are acutely or chronically. An aromatic hydrocarbon or arene (or sometimes aryl hydrocarbon) is a hydrocarbon with sigma bonds and delocalized pi electrons between carbon atoms forming a circle. In contrast, aliphatic hydrocarbons lack this delocalization. The term "aromatic" was assigned before the physical mechanism determining aromaticity was discovered, and referred simply to the fact that many .

Carcinogenic and Mutagenic Metal Compounds by E. Merian Download PDF EPUB FB2

ISBN: X OCLC Number: Notes: Papers presented at the Second IAEAC Workshop on Carcinogenic and/or Mutagenic Metal Compounds organized by the International Association of Environmental Analytical Chemistry and held in Villars-sur-Ollon, Switzerland, Jan.

in memory of Hans Wolfgang Nürnberg. Carcinogenic and Mutagenic Metal Compounds: Environmental and Analytical Chemistry and Biological Effects (CURRENT TOPICS IN ENVIRONMENTAL AND TOXICOLOGICAL CHEMISTRY) [Merian, Ernest] on *FREE* shipping on qualifying offers.

Carcinogenic and Mutagenic Metal Compounds: Environmental and Analytical Chemistry and. Carcinogenic and Mutagenic metal compounds Home. WorldCat Home About WorldCat Help. Search.

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Create Book, Internet Resource: ISBN: OCLC Number: Description: pages cm: Reviews. Bolognesi, P. Degan, in Biomarkers in Marine Organisms, 1. INTRODUCTION. Carcinogenic and mutagenic compounds are theoretically the most dangerous that occur in an ecosystem, as their effect may exert a damage beyond that of individual and may be active through several generations.

An alarming increase both in number and types of tumours found. The international pictogram for chemicals that are sensitising, mutagenic, carcinogenic or toxic to reproduction.

In genetics, a mutagen is a physical or chemical agent that changes the genetic material, usually DNA, of an organism and thus increases the frequency of mutations above the natural background level. Mechanisms of carcinogenicity are discussed for metals and their compounds, classified as carcinogenic to humans or considered to be carcinogenic to humans: arsenic, antimony, beryllium, cadmium.

In view of the overall findings in animals, there is sufficient evidence in experimental animals for the carcinogenicity of nickel compounds and nickel metal. Overall, the IARC () classified nickel compounds as carcinogenic to humans (Group 1), and metallic nickel as possibly carcinogenic to humans (Group 2B).

Chromium Cited by: 8. A carcinogen is any substance, radionuclide, or radiation that promotes carcinogenesis, the formation of may be due to the ability to damage the genome or to the disruption of cellular metabolic processes.

Several radioactive substances are considered carcinogens, but their carcinogenic activity is attributed to the radiation, for example gamma rays and alpha. Carcinogenic Mutaginic Metal C (Current Topics in Environmental and Toxicological Chemistry) [Frei, R. W., Hardi, W., Schlatter, Ch] on *FREE* shipping on qualifying offers.

Carcinogenic Mutaginic Metal C (Current Topics in Environmental and Toxicological Chemistry)Authors: Ch Schlatter, W.

Hardi, R. Frei. Abstract. Case reports of malignant tumors at sites of metal implants in humans and domestic dogs are reviewed; the results of carcinogenesis bioassays of implanted metallic nickel, chromium, and cobalt powders and alloys are summarized, and in vitro studies relevant to the carcinogenicity Carcinogenic and Mutagenic Metal Compounds book metallic compounds and alloys are briefly discussed.

These considerations Cited by: 1. Interactions by Carcinogenic Metal Compounds with DNA Repair Processes. In book: Selected Topics in DNA Repair cobalt and cadmium are carcinogenic, their mutagenic potentials are. compounds) - all "official" statements which are valid in Germany are to be found in one single book.

Einstufungen nach 67//EWG (Legaleinstufung), TRGS (Arbeitsplatzgrenzwerte), TRGS Casto, B., J. Meyers, and J. DiPaolo.

Enhancement of viral transformation for evaluation of the carcinogenic or mutagenic potential of inorganic metal salts. Cancer Res. –, PubMed Google ScholarAuthor: Max Costa. Metals and their compounds in the environment: occurrence, analysis, and biological relevance.

Merian, Thomas W. Clarkson. VCH, - Science - pages. 0 Reviews. From inside the book. What people are saying - Write a review. We haven't found any reviews in the usual places. Contents. The Composition of the Upper Earths Crust and the. This book attempts to demonstrate the complexity of the mechanisms of biological action of the toxic N-nitroso compounds.

The conclusions presented on genetic toxicology are based on comparative studies of biological assays and a firm foundation of chemical structural relations among N-nitroso. Determining Fingerprint Age with Mass Spectrometry Imaging via Ozonolysis of Triacylglycerols; Regioregular Head-to-Tail Poly(4-alkylquinoline)s: Synthesis, Characterization, Self-Organization, Photophysics, and Electroluminescence of New n-Type Conjugated Polymers.

Many translated example sentences containing "carcinogenic" – German-English dictionary and search engine for German translations. (e.g. R-phrases on carcinogenic and mutagenic effects). It is important to remember that certain metal oxides or other metal compounds (that is, the disperse or dispersible component thereof).

Heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) are chemicals formed when muscle meat, including beef, pork, fish, or poultry, is cooked using high-temperature methods, such as pan frying or grilling directly over an open flame (1).

In laboratory experiments, HCAs and PAHs have been found to be mutagenic—that is, they. @article{osti_, title = {Genetic toxicology of metal compounds. Enhancement of ultraviolet light-induced mutagenesis in Escherichia coli WP2}, author = {Rossman, T.G.

and Molina, M.}, abstractNote = {Salts of metals which are carcinogenic, noncarcinogenic, or of unknown carcinogenicity were assayed for their abilities to modulate ultraviolet (UV)-induced.

Mutagenesis / m juː t ə ˈ dʒ ɛ n ɪ s ɪ s / is a process by which the genetic information of an organism is changed, resulting in a may occur spontaneously in nature, or as a result of exposure to can also be achieved experimentally using laboratory procedures. The NIOSH Pocket Guide to Chemical Hazards is intended as a source of general industrial hygiene information for workers, employers, and occupational health professionals.

The Pocket Guide presents key information and data in abbreviated tabular form for chemicals or substance groupings (e.g., manganese compounds, tellurium compounds, inorganic tin.

Arsenic and arsenic compounds were considered by previous IARC Working Groups in, and (IARC, ). Since that time, new data have become available, these have been incorported in the Monograph, and. SGS: European Union to regulate 33 carcinogenic, mutagenic or reprotoxic (CMR) category 1A or 1B substances under new entry 72 to Annex XVII of REACH The European Commission has published a guideline with methods to assist the industry to comply with CMRs under entry 72 to Annex XVII of REACH.

Because our chemical environment affects our physical and mental well-being, it is a matter of increasing concern and is therefore attracting much research effort. This timely collection of essays highlights current developments in the field of environmental toxicology.

Chapters analyze the carcinogenic, mutagenic, genotoxic, and neurotoxic effects. Whether tetrachloroethylene and its metabolites are genotoxic (and if so at what doses) is an important consideration in evaluating potential modes of action for carcinogenic effects in the Environmental Protection Agency (EPA) draft Integrated Risk Information System (IRIS) assessment.

The evidence. Handbook on the Toxicology of Metals, Fourth Edition bridges the gap between established knowledgebase and new advances in metal toxicology to provide one essential reference for all those involved in the field.

This book provides comprehensive coverage of basic toxicological data, emphasizing toxic effects primarily in humans, but also those of animals and biological.

Benzene is a colorless, flammable liquid with a sweet odor. It evaporates quickly when exposed to air. Benzene is formed from natural processes, such as volcanoes and forest fires, but most exposure to benzene results from human activities. Benzene is among the 20 most widely used chemicals in the United States.

Landolph JR. Molecular and cellular mechanisms of transformation of C3H/10T1/2C18 and diploid human fibroblasts by unique carcinogenic, non- mutagenic metal compounds.

A review. Biol Trace Elem Res. ; – [Google Scholar]Cited by:   SCIENCE: Metal ions and carcinogenesis Chapter in book ‘ Cancer: Cell Structures, Carcinogens and Genomic Instability ’ (edited by Leon P. Bignold () Birkhäuser Verlag/Switzerland, pages ) by Troy R.

Durham and Elizabeth T. Snow of the Centre for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin. the protective effect of humates The increase in ionized radiation and pollution of our environment with herbicides, pesticides, heavy metal compounds, and other toxic mutagenic and carcinogenic substances presents a real danger to living organisms today and their progeny in the future.

A number of cohort studies involving workers exposed to formaldehyde have recently been completed. One study, conducted by NCI, looked at 25, workers in industries with the potential for occupational formaldehyde exposure and estimated each worker’s exposure to the chemical while at work (5).

The results showed an increased risk of death. The Report on Carcinogens is a congressionally mandated, science-based, public health document that NTP prepares for the HHS Secretary.

This cumulative report currently includes listings of agents, substances, mixtures, and exposure circumstances that are known or reasonably anticipated to cause cancer in humans. Mercury and Cancer – Research and Dental Amalgams. Published on Ma Mercury from amalgam fillings has been shown to be neurotoxic, embryotoxic, mutagenic, teratogenic, immunotoxic and clastogenic.

It is capable of causing immune dysfunction and auto-immune diseases. It is the high levels of carcinogenic compounds.